Double success for University drug resistance research

Swansea University research into the threat posed by antifungal drug resistance has been highlighted in two prestigious international journals. Fungal disease now kills more people than malaria or TB and the Centre for Disease Control in the USA recognises emergence of multi-drug resistance in fungi as a high level threat.

Dr Josie Parker and Prof Steve Kelly, from Swansea University Medical School's Centre for Cytochrome P450 Diversity have been involved in the studies which investigated different aspects of resistance

The first publication in the American Microbiology Society journal mBio saw them working with fellow academics from the University of Lausanne led by Professor Dominque Sanglard to compare whole genomes to identify key mutations involved in resistance to the drugs available that include azoles, amphotericin B and echinocandins.

A second publication in Nature Communications involved an international collaboration led by Manchester University's Professor Paul Bowyer and Dr Mike Bromley.

It examined drug resistance in the filamentous fungal pathogen Aspergillus fumigatus. Breathing in the airborne spores of this fungus can cause the devastating disease invasive aspergillosis which causes more than 200,000 life-threatening infections every year.

Professor Kelly, who has been researching the field of antifungal resistance for more than 30 years, said: "We are very pleased to be involved in both these research projects and that they have been published in such well-regarded journals.

"Improving our understanding of antifungal drug resistance will help in the development of effective and potentially life-saving therapies for the future."

Abhilash Kannan, Sandra A. Asner, Emilie Trachsel, Steve Kelly, Josie Parker, Dominique Sanglard.
Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae.
mBio Dec 2019, 10 (6). doi: 10.1128/mBio.02512-19.

Takanori Furukawa, Norman van Rhijn, Marcin Fraczek, Fabio Gsaller, Emma Davies, Paul Carr, Sara Gago, Rachael Fortune-Grant, Sayema Rahman, Jane Mabey Gilsenan, Emma Houlder, Caitlin H Kowalski, Shriya Raj, Sanjoy Paul, Peter Cook, Josie E Parker, Steve Kelly, Robert A Cramer, Jean-Paul Latgé, Scott Moye-Rowley, Elaine Bignell, Paul Bowyer, Michael J Bromley.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Nat Commun 11, 427 (2020). doi: 10.1038/s41467-019-14191-1.