"Anti-ROR gamma t therapies represent a ground-breaking opportunity that we are eager and motivated to pursue through our collaboration with Lead Pharma," said Christian Antoni vice president and head of the Immunology & Inflammation Franchise, Research & Development, Sanofi. "At Sanofi, we believe networked innovations - working collaboratively across science sectors - is the most effective way to bring meaningful new therapies to patients. To this end, Lead Pharma's innovative capabilities and productivity, exemplified by the ROR gamma t program, make them ideal partners for Sanofi in this area of drug discovery."
About Autoimmune Disorders
A wide range of human diseases are driven by deregulated immune function. There are hundreds of immune-mediated disorders that include joint diseases such as rheumatoid arthritis, inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Often these diseases are characterized by inappropriate activation of molecules termed cytokines, which are important mediators of normal immune function. When inappropriately activated, these powerful molecules can cause severe damage to multiple body systems. Manifestations of immune-mediated diseases range from mild skin rashes to severe organ failure to death. In addition to the significant suffering to patients, the socioeconomic burden of just rheumatoid arthritis has been estimated at approximately $40 billion in the U.S. alone.
About ROR gamma t
The nuclear receptor retinoic acid receptor-related orphan receptor gamma, also known as ROR gamma t or ROR gamma (t), is a key regulator of the cytokine immune pathway, interleukin (IL)-17, which lead to the differentiation of T cells to a pro-inflammatory subtype of T helper cells called Th17. As such, ROR gamma (t) drives the production of key pro-inflammatory proteins including IL-17A, IL-17F and the receptor for IL-23. Clinical studies validating the critical role of the IL-17 pathway in chronic autoimmune-related inflammation is growing. Recent findings that show the biological function of ROR gamma (t) can be moderated with small molecules have propelled this target to the cutting edge of drug discovery.
Sanofi, an integrated global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients' needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, and consumer healthcare, emerging markets, animal health and the new Genzyme. Sanofi is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).
About Lead Pharma
Lead Pharma started its activities at the Agri Food Health Innovation Centre and is currently located at both the Noviotech Campus in Nijmegen and the Pivot Park in Oss, the Netherlands. The company aims to discover and develop first or best in class small molecule drugs for the treatment of autoimmune diseases and cancer. Lead Pharma's drug discovery engine combines medicinal, structural, and computational chemistry with molecular pharmacology, cell and tissue-based pharmacology to select and advance the most promising molecules. Lead Pharma is a privately owned drug discovery company and is financed by Biox Biosciences, Participatiemaatschappij Oost Nederland N.V. (PPM Oost), Life Sciences & Health Fund B.V., and Technostartersfonds Zuid Nederland B.V.
1. J Rheumatol 2011;88;55-61; http://www.jrheum.org/content/88/55