R&D

Researchers find new signaling systems in human cells

The human cell has a wide variety of receptors on its surface that many molecules and therapeutic drugs can bind to in order to activate signals inside the cell to regulate different physiological functions. GPCRs are the largest - and a very important - family of receptors on human cells.

One avocado a day helps lower 'bad' cholesterol for heart healthy benefits

Move over, apples - new research from Penn State suggests that eating one avocado a day may help keep "bad cholesterol" at bay. According to the researchers, bad cholesterol can refer to both oxidized low-density lipoprotein (LDL) and small, dense LDL particles. In a randomized, controlled feeding study, the researchers found that eating one avocado a day was associated with lower levels of LDL (specifically small, dense LDL particles) and oxidized LDL in adults with overweight or obesity.

Rare diseases: Over 300 million patients affected worldwide

Rare diseases represent a global problem. Until now, the lack of data made it difficult to estimate their prevalence. Created and coordinated by Inserm, the Orphanet database, which contains the largest amount of epidemiological data on these diseases taken from the scientific literature, has made it possible to obtain a global estimate.

Bed time is the best time to take blood pressure medication

People with high blood pressure who take all their anti-hypertensive medication in one go at bedtime have better controlled blood pressure and a significantly lower risk of death or illness caused by heart or blood vessel problems, compared to those who take their medication in the morning, according to new research.

First entirely digital clinical trial encourages physical activity

As little as a daily ping on your phone can boost physical activity, researchers from the Stanford University School of Medicine and their collaborators report in a new study. The finding comes by way of the first-ever entirely digital, randomized clinical trial, which sought to answer two overarching questions: Is it feasible to successfully run an entirely digital, randomized clinical trial?

AI could offer warnings about serious side effects of drug-drug interactions

The more medications a patient takes, the greater the likelihood that interactions between those drugs could trigger negative side effects, including long-term organ damage and even death. Now, researchers at Penn State have developed a machine learning system that may be able to warn doctors and patients about possible negative side effects that might occur when drugs are mixed.

Antibody-based eye drops show promise for treating dry eye disease

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid. They are also the first to demonstrate that patients with dry eye disease experienced reduced signs and symptoms of the condition in response to a new eye drop treatment - made from pooled human antibodies - that targets ACPAs.

Research & Development

Researchers find new signaling systems in human cells

One avocado a day helps lower 'bad' cholesterol for heart healthy benefits

Rare diseases: Over 300 million patients affected worldwide

Bed time is the best time to take blood pressure medication

First entirely digital clinical trial encourages physical activity

AI could offer warnings about serious side effects of drug-drug interactions

Antibody-based eye drops show promise for treating dry eye disease

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